Synthesis of D-glucose-1-C-14 and D-mannose-1-C-14
نویسندگان
چکیده
منابع مشابه
A short synthesis of d-[1-(14) C]-serine of high enantiomeric purity.
Herein, we report a short, three-step synthesis of d-[1-(14) C]-serine (4) in high enantiomeric purity. Starting from [(14) C]-KCN and 2-(benzyloxy)acetaldehyde, Strecker reaction using (R)-1-phenylethylamine as the chiral auxiliary gave two diastereomeric aminonitriles 1 and 2 in the ratio of 4:3, which were conveniently separated and purified chromatographically. Following hydrolysis and subs...
متن کاملSynthesis of D-Glucose-1-C14 and D-Mannose-1-C14
Heretofore, radiochemical yields of sugars position-labeled with carbon-14 have been only 5 to 10 percent. This paper reports an improved cyanohydrin synthesis, and the preparation of D-glucose-1-C and D-mannose-1-C from D-arabinose in yields of about 50 percent. Low yields in prior syntheses appear to have been due to several inefficient steps, and to the fact that extension of the carbon chai...
متن کاملSynthesis of the C-glycoside of α-(D)-mannose-(1 → 6)-(D)-myo-inositol.
The dimannosylatedinositol pseudotrisaccharide phospholipid of the lipoarabinomannan (LAM) component of the mycobacterial cell wall has attracted interest as a therapeutic target because of its uniqueness to mycobacteria, its assembly at an early stage in LAM biosynthesis and the immunological activity of oligosaccharides containing this subunit. Accordingly, analogues of this pseudotrisacchari...
متن کاملSynthesis of ring labeled [ 1 ’ - 14 C ] - L - tyrosine Ryszard
The enzyme β-tyrosinase (tyrosine phenol lyase, EC 4.1.99.2) has been shown [8, 9, 15] to catalyze the decomposition of L-Tyr to phenol, pyruvate and ammonia. Under some conditions, this enzyme also participates in the reverse reaction leading to formation [10, 12, 13] of L-Tyr (Scheme 1). As a metabolism of L-Tyr is an important process of the living cells, the mechanism of the above reaction ...
متن کاملExcretion of (14)C-fumonisin B(1), (14)C-hydrolyzed fumonisin B(1), and (14)C-fumonisin B(1)-fructose in rats.
14C-Fumonisin B(1) (FB(1)) was produced by Fusarium proliferatum M-5991 in modified Myro liquid medium and purified to >95% purity with a specific activity of 1.7 mCi/mmol. Nine male and nine female F344/N rats were each dosed by gavage with 0.69 micromol of (14)C-FB(1), (14)C-hydrolyzed FB(1), or (14)C-FB(1)-fructose/kg body weight. Urinary excretion of (14)C-FB(1) and (14)C-FB(1)-fructose was...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Research of the National Bureau of Standards
سال: 1952
ISSN: 0091-0635
DOI: 10.6028/jres.048.023